Search results for " angewandte Wissenschaften::610 Medizin und Gesundheit"

showing 10 items of 24 documents

ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice: Review

2020

Submitted by (omml@ubi.pt) on 2021-07-05T10:37:14Z No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T11:16:44Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T11:20:07Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Made available in DSpace on 2021-07-05T11:20:07Z (GMT). No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: …

0301 basic medicineAllergyCARATComputer scienceIMPACTRespiratory Medicine and Allergy[SDV]Life Sciences [q-bio]computer.software_genreMedical and Health SciencesChange management (ITSM)Rhinitis.0302 clinical medicineQUALITY-OF-LIFEHDE ALERImmunology and AllergyLungmedicin och allergiSelf-managementRhinitis AllergicMultimediaAnamorphosisMOBILE TECHNOLOGYWORK PRODUCTIVITYdigital transformation of health and care3. Good healthsmernice ARIAAirway disease1107 ImmunologyGA(2)LENLife Sciences & BiomedicineASTHMA MULTIMORBIDITYe-zdravje600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und GesundheitARIA; asthma; CARAT; digital transformation of health and care; MASK; rhinitisSEASONAL ALLERGIC RHINITISMASKProcess (engineering)digital transformation of healthcareEUROPEAN INNOVATION PARTNERSHIPImmunologydigitalizacija zdravstvaARIA guidelines61003 medical and health sciencesQuality of life (healthcare)rhinitisHumansMobile technologyddc:610SELF-MANAGEMENTudc:616.2Science & TechnologyARIADigital transformationasthmaRespiration DisordersRhinitis AllergicMODEL030104 developmental biology030228 respiratory system3121 General medicine internal medicine and other clinical medicinee-healthClinical Medicinecomputer
researchProduct

Models for preterm cortical development using non invasive clinical EEG

2017

AbstractThe objective of this study was to evaluate the piglet and the mouse as model systems for preterm cortical development. According to the clinical context, we used non invasive EEG recordings. As a prerequisite, we developed miniaturized Ag/AgCl electrodes for full band EEG recordings in mice and verified that Urethane had no effect on EEG band power. Since mice are born with a “preterm” brain, we evaluated three age groups: P0/P1, P3/P4 and P13/P14. Our aim was to identify EEG patterns in the somatosensory cortex which are distinguishable between developmental stages and represent a physiologic brain development. In mice, we were able to find clear differences between age groups wit…

0301 basic medicineBrain developmentsomatosensory cortexmouse modelContext (language use)Neurosciences. Biological psychiatry. NeuropsychiatryBiologyElectroencephalographySomatosensory system600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::616 KrankheitenInterhemispheric coherence03 medical and health sciences0302 clinical medicine616medicineCoherence (signal processing)cortical developmentmedicine.diagnostic_testGeneral Neurosciencephase amplitude couplingNon invasivetelemetrycoherence030104 developmental biologypigletfull band eegpretermNeuroscience030217 neurology & neurosurgeryPhase amplitude couplingRegular ArticlesRC321-571Translational Neuroscience
researchProduct

Q-nexus: a comprehensive and efficient analysis pipeline designed for ChIP-nexus

2016

Background: ChIP-nexus, an extension of the ChIP-exo protocol, can be used to map the borders of protein-bound DNA sequences at nucleotide resolution, requires less input DNA and enables selective PCR duplicate removal using random barcodes. However, the use of random barcodes requires additional preprocessing of the mapping data, which complicates the computational analysis. To date, only a very limited number of software packages are available for the analysis of ChIP-exo data, which have not yet been systematically tested and compared on ChIP-nexus data. Results: Here, we present a comprehensive software package for ChIP-nexus data that exploits the random barcodes for selective removal …

0301 basic medicineFOS: Computer and information sciencesDuplication ratesChromatin ImmunoprecipitationBioinformaticsPipeline (computing)610Biologycomputer.software_genre600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit03 medical and health sciencesSoftwareChIP-nexusGeneticsPreprocessorNucleotide MotifsLibrary complexityChIP-exoGeneticsProtocol (science)Binding Sitesbusiness.industryfungiComputational BiologyHigh-Throughput Nucleotide SequencingReproducibility of ResultsChipChromatin immunoprecipitationData mappingDNA-Binding ProteinsAlgorithm030104 developmental biologyChIP-exoData miningbusinessPeak callingcomputerAlgorithmsSoftwareProtein BindingTranscription FactorsResearch ArticleBiotechnologyBMC Genomics
researchProduct

Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients

2017

The immunomodulatory role of human leukocyte antigen (HLA)-E in hematopoietic stem cell transplantation (HSCT) has not been extensively investigated. To this end, we genotyped 509 10/10 HLA unrelated transplant pairs for HLA-E, in order to study the effect of HLA-E as a natural killer (NK)-alloreactivity mediator on HSCT outcome in an acute leukemia (AL) setting. Overall survival (OS), disease free survival (DFS), relapse incidence (RI) and non-relapse mortality (NRM) were set as endpoints. Analysis of our data revealed a significant correlation between HLA-E mismatch and improved HSCT outcome, as shown by both univariate (53% vs. 38%, P=0.002, 5-year OS) and multivariate (hazard ratio (HR)…

0301 basic medicineOncologyAdultMalemedicine.medical_specialtyTransplantation ConditioningAdolescentGenotypemedicine.medical_treatment610Hematopoietic stem cell transplantationHuman leukocyte antigen600 Technik Medizin angewandte Wissenschaften::610 Medizin und GesundheitArticle03 medical and health sciencesYoung Adult0302 clinical medicineCell Therapy & ImmunotherapyInternal medicineMedicineHumansTransplantation Homologousddc:610Potassium Channels Inwardly RectifyingSurvival analysisAllelesAgedBone Marrow TransplantationAcute leukemiabusiness.industryDonor selectionHistocompatibility TestingHazard ratioHistocompatibility Antigens Class IHematopoietic Stem Cell TransplantationHematologyMiddle Agedmedicine.diseasePrognosisSurvival AnalysisTransplantationLeukemiaLeukemia Myeloid Acute030104 developmental biologyTreatment OutcomeImmunologyFemalebusiness030215 immunology
researchProduct

Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties.

2016

Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the Adverse Outcome Pathway Knowledge Base, support the development of these methods. The aim of the project presented in this publication was to develop substance categories for a read-across with complex endpoints of toxicity based on existing databases. The basic conceptual approach was to combine str…

0301 basic medicineQuantitative structure–activity relationshipread acrossPredictive Clustering Tree (PCT) methodComputer science610010501 environmental sciencescomputer.software_genre600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit01 natural sciences03 medical and health sciencesPharmacology (medical)Cluster analysis0105 earth and related environmental sciencesOriginal ResearchAlternative methodsPharmacologytoxicological and structural similaritybusiness.industryQSARlcsh:RM1-950non-animal methods; QSAR; readacross; Predictive Clustering Tree (PCT) method; toxicological and structural similarityIdentification (information)Tree (data structure)030104 developmental biologyConceptual approachlcsh:Therapeutics. PharmacologyKnowledge basenon-animal methodsData miningWeb servicebusinesscomputerFrontiers in pharmacology
researchProduct

ARIA���EAACI statement on asthma and COVID���19 (June 2, 2020)

2021

Artículo con numerosos autores sólo se mencionan el primero y el de la UAM

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)AllergyStatement (logic)MedicinaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)virusesImmunology610Settore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.disease_cause03 medical and health sciences0302 clinical medicineastmaMedicine and Health SciencesmedicineHumansImmunology and Allergy030212 general & internal medicineLetters to the EditorLetter to the Editorudc:616.2AsthmaCoronavirusScience & Technologybusiness.industrySARS-CoV-2virus diseasesCOVID-19asthmamedicine.diseaseVirologyAsthma3. Good health030228 respiratory systemcovid-191107 ImmunologyAngiotensin-Converting Enzyme 2businessARIA-EAACILife Sciences & Biomedicine600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
researchProduct

Focal Cortical Lesions Induce Bidirectional Changes in the Excitability of Fast Spiking and Non Fast Spiking Cortical Interneurons

2014

A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unknown whether specific interneuronal subpopulations contribute differentially to such pathological condition. In the present study we investigated functional alterations of inhibitory interneurons embedded in a hyperexcitable cortical circuit at the border of chronically induced focal lesions in mouse …

500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie570Neural NetworksPostsynaptic CurrentExcitotoxicity610lcsh:MedicineNeurophysiologyAction PotentialsNeural Homeostasis600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheitmedicine.disease_causeInhibitory postsynaptic potentialMiceEpilepsyInterneuronsmedicineBiological neural networkAnimalslcsh:ScienceVisual CortexCerebral CortexMembrane potentialMultidisciplinarymusculoskeletal neural and ocular physiologylcsh:RNeurotransmissionBiology and Life SciencesExcitatory Postsynaptic Potentialsmedicine.diseaseVisual cortexmedicine.anatomical_structurenervous systemCellular NeuroscienceExcitatory postsynaptic potentiallcsh:QNeuroscienceResearch ArticleNeurosciencePLoS ONE
researchProduct

Psychological distress among refugees in Germany: a cross-sectional analysis of individual and contextual risk factors and potential consequences for…

2020

Objectives Responding to the mental health needs of refugees remains a pressing challenge worldwide. We estimated the prevalence of psychological distress in a large refugee population in Germany and assessed its association with host country factors amenable to policy intervention and integration indicators.Design A cross-sectional and population-based secondary analysis of the 2017 wave of the IAB-BAMF-SOEP refugee survey.Setting Germany.Participants 2639 adult refugees who arrived in Germany between 2013 and 2016.Main outcome measures Psychological distress involving symptoms of depression, anxiety and post-traumatic stress disorder was measured using the Refugee Health Screener-13.Resul…

AdultMaleRefugeesEpidemiologypublic healthR6101692Stress Disorders Post-TraumaticCross-Sectional Studiespsychological distressRisk FactorsGermanyddc:330HumansMedicineFemale1506mental health600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und GesundheitAgedrefugees in Germany
researchProduct

Omalizumab rapidly improves angioedema-related quality of life in adult patients with chronic spontaneous urticaria: X-ACT study data

2018

Background The X-ACT study aims to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1-antihistamines. Methods In X-ACT, a phase III, double-blind, placebo-controlled study, CSU patients (18–75 years) with ≥4 angioedema episodes during the 6 months before inclusion were randomized (1:1) to receive omalizumab 300 mg or placebo every 4 weeks for 28 weeks. Angioedema-related QoL, skin-related QoL impairment, and psychological well-being were assessed. Results Ninety-one patients were randomized and 68 (omalizumab, n=35; placebo, n=33) completed the 28-week treatment period. At baselin…

AdultMalechronic spontaneous urticariamedicine.medical_specialtyAdolescentUrticariaImmunologyOmalizumab600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::616 KrankheitenPlaceboYoung Adult030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineDouble-Blind MethodRefractoryQuality of lifeInternal medicine616Anti-Allergic AgentsmedicineHumansH1-antihistamine-refractoryImmunology and AllergyDepression (differential diagnoses)AgedAngioedemaAdult patientsbusiness.industryangioedemaDermatology Life Quality IndexMiddle AgedSurgeryquality of life030228 respiratory systemExperimental Allergy and ImmunologyomalizumabOriginal ArticleFemaleORIGINAL ARTICLESH1‐antihistamine‐refractorymedicine.symptombusinessmedicine.drugAllergy
researchProduct

Auditory Mismatch Negativity and Repetition Suppression Deficits in Schizophrenia Explained by Irregular Computation of Prediction Error

2015

Background The predictive coding model is rapidly gaining attention in schizophrenia research. It posits the neuronal computation of residual variance (‘prediction error’) between sensory information and top-down expectation through multiple hierarchical levels. Event-related potentials (ERP) reflect cortical processing stages that are increasingly interpreted in the light of the predictive coding hypothesis. Both mismatch negativity (MMN) and repetition suppression (RS) measures are considered a prediction error correlates based on error detection and error minimization, respectively. Methods Twenty-five schizophrenia patients and 25 healthy controls completed auditory tasks designed to el…

AdultMalemedicine.medical_specialtyAdolescentSchizophrenia (object-oriented programming)lcsh:Medicine610Mismatch negativitySensory systemAudiologyElectroencephalography600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheitbehavioral disciplines and activitiesCorrelationYoung AdultEvent-related potentialmedicineHumansComputer Simulationlcsh:ScienceMultidisciplinarymedicine.diagnostic_testlcsh:RRepeated measures designMiddle AgedEvoked Potentials AuditorySchizophrenialcsh:QFemaleSchizophrenic PsychologyAnalysis of variancePsychologyResearch ArticlePLoS ONE
researchProduct